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In the low-overdose patient (A), the maximum number of necrosed cells was 46 of 5,114 cells (0.89%) without zonation, which increased to 79 necrosed cells when applying 80% zonation (see Figure 4)

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Although CTR1 regulates cellular uptake of copper, its removal is mediated by two P-type ATPases, ATP7A and ATP7B, and ATP7B is closely related to resistance to platinum drugs through regulation of efflux (Martinez-Balibrea et al., 2009)

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