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TNF- can make quiescent hepatocytes more sensitive to growth factors, early elevation of TNF- during APAP toxicity may be an important factor in stimulating hepatocytes and promoting late liver regeneration [225]

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Critical as well as deceased COVID-19 patients demonstrate significantly lower serum levels of EPO, haptoglobin, and hepcidin compared to survivors or mild cases 439

FcRn antagonists may also be used in combination with other specific treatment regimens, for instance, targeting activation of complement and/or immune cells in diseases with a high inflammatory burden, to further improve the therapeutic outcome

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