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Nanotechnology has received a great attention as it can resolve problems linked to the conventional therapeutic agents, such as lack of targeting capability, poor water solubility, systemic toxicity, and nonspecific distribution (Sreelakshmi et al., 2018)

After purification, the enzyme and acid dual-responsive polymer BEAGA 2 -PEG 2k -PDHD was finally obtained

15, 16 Primary antibodies to mouse K14 (ab7800, 1:500), p63 (ab53039, 1:100), PCNA (ab29, 1:200) and cleaved Caspase3 (ab13847, 1:100) were purchased from Abcam

STUB1 plays a central role in protein quality control by linking molecular chaperones to the UPS, playing a critical role in proteostasis (VanPelt and Page, 2017)

The elevated ratio of CSF/serum albumin and reduced expression of BSCB TJs proteins has been reported in both forms of this disease [110]

As seen in the experiments with CdCl 2 , the CDO-induced perturbation of glutathione production could have a significant effect on the redox capacity of the cell