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Cytosolic GPX4 has been identified as the only GPX4 isoform being essential for embryonic development and cell survival

GR stands for glutathione reductase and it's an enzyme that converts oxidized glutathione into a more active, bioavailable version of glutathione, known as 'reduced glutathione'

Nucleus pulposus cells, while theoretically most advantageous due to their ability to adapt to the harsh intradiscal environment and synthesize specific matrix, are limited in number in degenerated discs, their acquisition is invasive, and they are difficult to use for repairing the annulus fibrosus and endplate, limiting clinical application

Courtin, Ensemble Contre le Mlanome, the Foundation Crdit Mutuel, Foundation Carrefour and the association Vaincre le Mlanome for their ongoing research funding support

Lastly, Ucn 3 mRNA and peptide expression have been identified in the amygdala, lateral septum, ventromedial hypothalamus and paraventricular nucleus of the hypothalamus, basomedial nucleus of the stria terminalis, dorsal raphe nucleus and the area postrema (Lewis et al., 2001

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