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initially showed that icv injection of somatostatin-28 or ODT8-SST abolished the plasma epinephrine elevation elicited by a variety of stressors including acute exposure to tail suspension, intermittent loud noise, ether stress, or metabolic hypoglycemic stress induced by the injection of 2-deoxyglucose or insulin in rats (Fisher and Brown, The centrally mediated action of the SST-agonists was demonstrated by the lack of effect when ODT8-SST was administered peripherally at a dose 100-times higher than icv (Fisher and Brown, 1984)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Mikus D., Sikiric P., Seiwerth S., Petricevic A., Aralica G., Druzijancic N., Rucman R., Petek M., Pigac B., Perovic D., et al

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This injection plays an essential role in improving metabolic activity, supporting nervous system function and promoting overall animal performance