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npj Viruses

The study demonstrated that KPV could effectively inhibit NF-kappaB activation and reduce inflammatory cytokines in corneal and dermal cells, suggesting broad therapeutic potential for inflammatory skin conditions

10 Separately, a -glucogallin-standardized amla extract produced larger reductions in fasting and post-prandial glycemia and HbA1c than metformin (500 mg/day) in newly diagnosed type 2 diabetes with dyslipidemia

Mechanistically, upon reperfusion, Kupffer cells are activated and produce large amounts of ROS and cytokines (TNF, IL-1) that kill hepatocytes

However, 2D cultures oversimplify the cellular architecture and fail to capture the complex brain microenvironment ( in vitro models (Zivko et al., 2024)

Given the difficulty in treating susceptible versions of these disease-causing bacteria in a conflict zone, it is imperative to better understand resistance drivers for these infections