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Advanced degenerative conditions severely degenerated cartilage or end-stage joint disease involves tissue that may be beyond repair acceleration

Although oxidative damage in biological systems has in the past been completely attributed to ROS, it is becoming increasingly clear that also reactive nitrogen species (RNS) and reactive sulfur species (RSS) are integral components of signal transduction processes in cells, and play important roles in OS generation [2, 25, 35]

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Yokozawa T, Kim YJ

[136] reported that N-CQDs significantly reduced fungal counts in both in vitro assays and an in vivo rat model of mucormycosis, with antifungal effects attributed to ROS generation, disruption of fungal cell wall integrity, and increased membrane permeability [136]

We first confirmed that the addition of alkyne handles to SCLA1-4 did not ablate senolytic activity (Extended Data Fig