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10.1016/j.jtemb.2016.02.006 22 BozkusF.GulerS.SmsekS

These radicals can further damage mitochondrial DNA, proteins, and lipids, impairing mitochondrial function and reducing ATP production, which is essential for cardiac muscle contraction [87]

Miller R, Buehner G, Chang Y, Harper JM, Sigler R, Smith-Wheelock : Methionine deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-1 and insulin levels and increases hepatocyte MIF levels and stress resistence

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This association plays an important role in the progression of diabetes