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Together, the outcome could result in serious neurological diseases including ALS, frontotemporal lobar degeneration, Alzheimer's disease, and others (56)

Typically, the human antibody can have up to twenty positions replaced with amino acid residues which are not part of the human germline immunoglobulin sequence

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Conclusion The pathogenesis of PD originates from complex interactions between genetic susceptibility and environmental factors, ultimately converging into four core pathological events: -syn misfolding, mitochondrial dysfunction, OS, and neuroinflammation