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The present review also highlight molecular elements that are currently targeted in GBM clinical trials and others that represent promising potential new targets

10.1016/j.resmic.2010.11.005 Res Microbiol

Stopping biologic therapy or immunosuppressants without medical guidance can trigger a flare

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Recombinant human IGF-I was first available for experimental therapy in the late 1980s, what allowed the development of long-term studies in children with severe primary IGF-I deficiency (defined as a height SDS and IGF-I SDS less than or equal to 3 and normal or elevated GH levels) [375]