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Indeed, it has been reported that (i) CD38 inhibits CD8 + T-cell functions via ADO receptor signaling (76), while either (ii) inhibiting CD38 or blocking ADO receptors was effective in overcoming resistance to combined ICP immunotherapeutic strategies (92)

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Summary Table Mechanism of Action BPC-157 Stimulates angiogenesis through upregulation of Vascular Endothelial Growth Factor (VEGF)