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With established analytical methods for performing the metabolite analysis of substances present in medicinal or herbal plants, including amino acids, sterols, hormones, sugars, catecholamines, aromatics, fatty acids, etc., this methodology is one of the most systematic in the field of metabolomics

Study Methodology Inclusion criteria included: BMI over 25 Age between 45 to 70 years No supplement consumption in the past three months No weight loss diet in the past three months No participation in other intervention programs Willingness to lose weight No history of heart, liver, kidney disease, diabetes, hypothyroidism, rheumatoid arthritis, or surgery After signing the informed consent form, participants were randomly assigned to an intervention group (21 individuals) and a control group (22 individuals)

If the MVR becomes more severe, with more blood flowing the wrong way, the heart must work harder to pump sufficient oxygenated blood around the body and the upper chamber of the heart can become dilated due to increased pressure

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