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The fake-period effects are not exactly zero (averaging about -6.0 packs), reflecting the reduced pre-treatment fit when the training window is shortened from 9 years (19801988) to 5 years (19801984)

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Based on a power calculation using the Clincalc.com (ClinCalc LLC, Arlington Heights, IL, USA) sample size calculator with an assumed average BP of 120 mmHg, a BP variability of 5 mmHg, a clinically relevant difference of 6 mmHg, an enrollment ratio of 3, an alpha of 0.05, and a power of 80%, at least 28 participants, of which at least 7 in each of the cessation and relapse groups, were to be included

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