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Per the requirement of the FDA, echocardiographic monitoring is mandatory for the fenfluramine-treated Dravet syndrome patients, including before starting the drug, during the course of therapy, and follow-up evaluation 36 months after treatment conclusion to detect any implicit valvulopathy associated with drug use

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Incorporating a high level of Se (3 mg/kg) into the chickens diet induced oxidative stress characterized by low SOD and catalase activities (204)

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