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Mol Pharmacol 72:2939 Shinojima N, Yokoyama T, Kondo Y, Kondo S (2007) Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy

Studies show that CrAT overexpression in primary human skeletal myocytes increases glucose uptake and attenuates lipid-induced suppression of glucose oxidation, demonstrating the importance of carnitine-dependent metabolic pathways in preserving insulin sensitivity and metabolic health

Thus, PDK suppresses the metabolic shift from glycolysis to the TCA cycle by downregulating PDH, thereby reducing mitochondrial ROS production and suppressing cell death [24,25]

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201 In breast cancer, elevated HSP90 levels stabilize estrogen receptor (ErbB)-dependent PI3K/AKT and ERK signaling pathways, counteracting the effects of hormonal therapies such as fulvestrant

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