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All media were supplemented with 10% FBS (Gemini Bio Products) and all cells were maintained at 37 C in 5% CO 2

In controlled clinical trials, daily intakes of aged garlic extract at doses between 1.2 g-2.4 g (containing 1.2 to 2.4 mg of S-allyl-L-cysteine) consistently resulted in reductions in SBP by 9 mm Hg-10 mm Hg and reductions in DBP by 4 mm Hg-8 mm Hg in a majority of patients with uncontrolled hypertension (110, 143)

Vitamin C: This is perhaps the most important partner for glutathione

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doi: 10.1016/j.cell.2012.03.042 5 AholaSLangerT

Metabolic effect by cytochrome P450 It was observed that drugs that undergo extensive metabolism by CYP450 enzymes are generally considered more likely to cause DILI compared to drugs that are not metabolized