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Given the plethora of information on the immunological pathophysiology of MS and the accessibility of existing drugs as well as novel ones in development, the future seems promising for managing and treating MS

While tests such as CVLT, BNT, and UPSIT offer valuable diagnostic insight, particularly in early or prodromal stages, their limited dynamic range and susceptibility to ceiling or floor effects constrain their utility as response biomarkers

doi: 10.1038/s41429-022-00537-3 214 StephensC.ArismendiT.WrightM.HartmanA.GonzalezA.GillM.et al

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Chronic treatment of RT has been long used in the effective induction of PD both in Rat 44,45,46 and zebrafish models 47,48,49