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Furthermore, studies done with acetylcholinesterase inhibitors, which are common AD treatments, showed the reversibility of reactive astrocytes to a healthy state after treatment 151

confirmed increased small nerve fibre abundance in both skin and cornea Sarcoidosis-associated small fibre neuropathy Phase 2 RCT confirmed ARA-290 produced relief of neuropathy-related symptoms in sarcoidosis patients with moderate-to-severe neuropathic pain, with approximately 50% response rate versus placebo

Accessed 12/1/2020, Wu V, Sykes EA, Beyea MM, Simpson MTW, Beyea JA

The role of the gut microbiome in the healthy adult status

425 Studies have found that NOD2 expression on basophils in the peripheral blood of AD cases is markedly reduced compared with that of healthy people, 426 and basophils are the main effector cells involved in Th2 polarization in allergic inflammation

Identification of novel genes coding for small expressed RNAs