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Phylogenetic analysis of APXs To analyze the evolutionary relationship between identified APX homologs, the phylogenetic tree was constructed by MEGA 6 using the Maximum Likelihood (ML) method with 1000 bootstraps (Figure 5)

Reduced fatty acid oxidation and mitochondrial dysfunction lead to an increase in the AMP/ATP ratio, which has an immediate effect on renal PTECs by consuming abundant ATP (29)