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Researchers monitoring GI adverse events should collect data on meal patterns to differentiate compound-related GI effects from dietary confounders, particularly during the first 812 weeks of dose escalation when GI adverse events are most frequent

Short answer possibly

N Engl J Med 2012;367, 795-804, doi:10.1056/NEJMoa1202753

Including cyanocobalamin in the injection ensures adequate B12 replacement to prevent neurological complications and megaloblastic anemia that can develop over months of restricted intake

Novo Nordisk plans to start late-stage trials of obesity drug amycretin next year

Some clinical reports describe improvements in hair density and follicle health in patients using GHK-Cu-containing topical formulations or injectable protocols, though more controlled human trials are needed in this area