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In parallel, an increase in NAMPT activity boosts autophagy, 86,89 while a decrease in OCT4 enhances autophagy inhibition

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Costa I, Barbosa DJ, Benfeito S, Silva V, Chavarria D, Borges F, Remio F, Silva R (2023) Molecular mechanisms of ferroptosis and their involvement in brain diseases

Leaky gut development: Factors like harmful bacteria imbalance, lectins (plant proteins), environmental toxins, and certain medications can compromise these otherwise tight junctions, leading to leaky gut

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As the oxidative burden on the mitochondria is lifted, these organelles can begin to shift away from inefficient anaerobic glycolysis (which produces the brain-fog-inducing lactate) and back toward efficient aerobic ATP production