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All data are expressed as the mean SD from at least three biological replicates, and comparisons between the two groups were performed with a nonparametric method (MannWhitney U test)

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In addition, pharmacological and genetic suppression of this pathway prevented the differentiation of myeloid descendant cells into MDSCs, leading to significant tumor regression in mice [67]

[DOI] [PMC free article] [PubMed] [Google Scholar] 91.Romero S.M., Alberto M.R., Manca D.N.M., Vaamonde G

Before this work, we knew the ER needed to stay oxidized to fold proteins correctly, but the machinery responsible for maintaining that balance was essentially a black box, says Gad