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It is thought that soluble RAGE acts as a decoy receptor and is protective against the accumulation of amyloid-beta.[ref][ref] One example of how soluble RAGE acts to decrease AGEs can be found in osteoarthritis

The peptide space is moving fast, and some of these compounds may prove genuinely valuable for human longevity

Most mutations (including the p.Gly376Asp) promote cytoplasmic mislocalization [20] and formation of toxic protein aggregates [21], coupled to a depletion TDP-43 in the nucleus that causes a loss of the nuclear function of the protein [22]