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Dairy cows with ketosis exhibit sustained lipolysis, local inflammation, and insulin resistance of adipose tissue [48]

For muscle mass maintenance, the group confirmed that gonadal sex plays a stronger role such that all mice with testes had greater absolute mass of EDL, gastrocnemius, TA, and quadriceps

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*Non-GM

While subtracting the effect from endogenous transporters suggests YDR338C and YMR253C transport ACA concentratively, further experiments are needed to verify the results

This controlled and consistent drug delivery also helps reduce systemic side effects by eliminating peak concentrations on bolus (injection) administration