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They are highly expressed in the cytoplasmic and mitochondrial compartments of cardiomyocytes and represent an important defense mechanism within the heart [4, 7]

Another example is the study of Ma et al., who developed chitosan NPs-inlaid poly-l-lactide porous microparticles co-loaded with two antidiabetic agents, including GLP-1 and small interfering RNA (siRNA), to inhibit the expression of dipeptidyl peptidase-4 mRNA