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Small-molecule probes, such as TSQ and Zinquin, pioneered live-cell imaging in the 1990s, although early designs were limited by poor selectivity and lack of organelle specificity 185,186

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Like KPV, the FDA found no human studies supporting its proposed applications

The investigation further revealed an augmentation in the expression of purinergic receptors P2Y2 and P2X7, alongside an alteration in the ratio of pERK1/2/ERK1/2 and pCAMKII/CAMKII