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, originally developed at the University of Arizona, is a synthetic analog of the naturally occurring melanocortin peptide hormone alpha-melanocyte stimulating hormone (-MSH) that has been shown to induce skin pigmentation through melanogenesis and thereby subsequently reduce sun (UV) damage to UV exposed skin in preliminary studies and clinical trials

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Both classes mediate a complex interplay between host gene regulation and HIV-1, contributing to viral pathogenesis and associated neurodegenerative disorders [52, 53]

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