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Fanuli et al., Macrophage polarization in chronic inflammatory diseases: Killers or builders

The iron moiety of hemoglobin can be oxidized to the Fe 3+ state to form methemoglobin

10.2217/fon-2018-0040 176 SunR.LiuJ.YuM.XiaM.ZhangY.SunX.et al (2022)

However, uncontrollable release in other macrophage phenotypes or cells causes dose-dependent toxicity, which attributes to nonspecifically chelate physiologically essential iron

156 Besides, with the consumption of extracellular glutamine, GDH can also catalyze ammonia derived from glutaminolysis and -KG to support the synthesis of glutamate and downstream metabolites by reductive amination in a NADPH consumption manner to meet the cancer cells growth