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doi: 10.3390/ANTIOX10081266 114 PawankarRMoriSOzuCKimuraS

Other proteins that bind KEAP1 and interfere with KEAP1-NRF2 interaction, promoting NRF2 accumulation and function in the nucleus, include: phosphoglycerate mutase 5 (PGAM5, a serine/threonine phosphatase related to the phosphoglycerate mutase family), which has been reported to be associated with mitochondria, so its interaction with KEAP1 may be regulated by mitochondrial signalling processes [187, 188]

NF-B, MAPK) to affect COX/LOX expression, manipulating downstream eicosanoid synthase expression, altering the production of specific eicosanoids, and disrupting eicosanoid feedback loops

It also supports healthy circulation and already-healthy blood pressure levels through vasodilation

95% CI=0.21-5.04)

The BBB is a dynamic barrier, and its protective function is achieved by the presence of metabolizing enzymes, multiple membrane transporters and receptors, as well as interaction with the brain parenchymal cells accounting for 80% of the brain tissue volume (15)