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Abnormal neural progenitor cells differentiated from induced pluripotent stem cells partially mimicked development of TSC2 neurological abnormalities

doi:10.1016/j.clnesp.2021.09.004

doi: 10.1530/EJE-17-0041 129 KarsMvan der KlaauwAAOnsteinCSPereiraAMRomijnJA

50 & Target In Vitro L-Tyrosine inhibits citrate synthase activity in the posterior cortex (2.0 and 4.0 mM), malate dehydrogenase is not altered by L-Tyrosine and succinate dehydrogenase is increased in the posterior cortex (0.1-4.0 mM), hippocampus (1.0-4.0 mM), striatum (4.0 mM) and liver (0.1-4.0 mM)

Role Chair

(2016) Atomic-resolution structure of amyloid fibrils