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Insulin resistance also lowers the synthesis of hepatic sex hormone-binding globulin (SHBG), further increasing free androgen levels (Song and Choi, 2022)

In addition to downregulation of injury and inflammation-related pathways, GSEA also revealed suppression of adipogenesis-related pathways in the liver of GPR146-deficient mice, suggesting that GPR146 may promote hepatic steatosis via PPAR-mediated transcriptional programs (Fig

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To directly demonstrate the effect of CoQ 10 H 2 on adipocyte differentiation and lipolysis, 10 M CoQ 10 H 2 was added to pre-adipocyte 3T3L1 cultures before (Day 0) and after (Day 5) differentiation, and lipid accumulation was quantitatively determined by oil red O staining (Fig