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DECLARATIONS Authors contributions Drafted the manuscript: Valds-Calero I Revised the manuscript critically for important intellectual content: Rodrguez A, Frhbeck G All authors participated in final approval of the version to be published

Stengel and Tach, 2014b)

Overexpression of NNT increased NADPH/NADP + resulting in reductive stress in melanoma cells (23)

Monocytes and macrophages that express pro-inflammatory markers clear cellular debris and promote myogenic cell proliferation 1,60

However, whether the EAT-reducing effects of GLP-1 RA are independent of their weight loss-inducing properties continues to be debated