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TRPA1 sensitization during diabetic vascular impairment contributes to cold hypersensitivity in a mouse model of painful diabetic peripheral neuropathy

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No validated human pharmacokinetics A human half-life, bioavailability, tissue distribution, metabolic pathway and exposure-response relationship have not been established through a published clinical programme

Many growth factors show similar patterns where optimal stimulation occurs within a narrow concentration window, and excess amounts trigger inhibitory feedback