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These issues motivate the use of mucoadhesive gels/films, nanomicelles/phytosomes/cyclodextrins, and photosensitizer formulations for aPDT to enhance solubility, retention, and local bioavailability

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Clearance of a drug is the factor that predicts the rate of elimination in relation to the drug concentration (C): Clearance, like volume of distribution, may be defined with respect to blood (CL b ), plasma (CL p ), or unbound in water (CL u ), depending on where and how the concentration is measured