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The comparison of pineal and GIT melatonin generation (5, 6, 28) shows that pineal melatonin is secreted in circadian fashion, while GIT production of this indole exhibits the episodic rises closely related to food intake, probably due the biosythesis of indole from the tryptophan originating from the digested proteins in GIT

Park ES, Gao X, Chung JM, Chung K

Ranjan, A., Ramachandran, S., Gupta, N., Kaushik, I., Wright, S., Srivastava, S., Das, H., Srivastava, S., Prasad, S., & Srivastava, S

doi: 10.1016/j.cmet.2024.01.005 66 GruossoTGigouxMManemVSKBertosNZuoDPerlitchIet al

H., Mohammed, A