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miR-223 is not transcribed or processed in endothelial cells and HDL delivery of mature miR-223 to endothelium likely confers, in part, HDLs anti-inflammatory capacity associated with adhesion molecule suppression

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10.1126/science.1221592 Science 67 PandaS.AntochM.MillerB

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As a result of this activation, SP, a neurotransmitter that plays a role in transmitting and modulating pain signals, is released (Zieglgnsberger, 2019)