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When applied together with reperfusion treatments, TRPM4 blocking antibody has the potential to extend the therapeutic time window for acute ischemic stroke

The anxiolytic mechanism of Selank involves modulation of GABAergic neurotransmission through allosteric effects on GABA-A receptor sensitivity, distinct from the direct binding site used by benzodiazepines

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Mak AL, Augustijn QJJ, Heymann CJF, Havik S, Verdoes X, Rios-Morales M, Bosmans LA, Verheij J, Meijnikman AS, de Jonge PA, et al

(310) found cycles of repeated low dose TLR7/8 agonist injection within 24h with intervals every five days, compared to one high dose injection every three days, significantly suppressed tumor growth in a mouse model (310), indicating the potential of circumventing TLR tolerance by adjusting treatment dose and time

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