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The observed plasma increase in adenosine could be due to a decrease in adenosine deaminase activity, inhibition of adenosine kinase, or an increase in 5-nucleotidase, all of which can occur in the presence of oxidative stress [7072]

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Exogenously administered agents in the form of a pill containing estrogen/progestin flood the bloodstream to acts upon the female genital tract and more importantly the brain to interrupt the normal hormonal feedback loop that exists between the brain and gonads