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This implies that extracellular vesicles may serve as a possible readout of disease state in addition to being a source of future omics data

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(2014) DUX4 may activate CDKN1A expression through the bone morphogenetic protein ( BMP ) -2 signalling pathway, which is an upstream actor of Sp1

These observations suggest that spinogenesis during very early development might skip a filopodial sampling phase, although the requirement for presynaptic axon proximity seems preserved

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