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Multiple rounds are necessary for some patients (mainly women), and almost all patients experience side effects in high doses as well as a purging period that can last for months

GPX4 prevents ferroptosis by reducing phospholipid peroxidation (Xie et al., 2023)

Guzy et al

Benjamin D, Robay D, Hindupur SK, Pohlmann J, Colombi M, El-Shemerly MY, Maira SM, Moroni C, Lane HA, Hall MN (2018) Dual inhibition of the lactate transporters MCT1 and MCT4 is synthetic lethal with metformin due to NAD+ depletion in cancer cells

Proceedings of the American Association for Cancer Research Annual Meeting 2020 2020;80(16):Abstract nr 248 42

The examination of prior studies resulted in different findings for the same treatment received due to potential confounding variables or biases not considered or not statistically controlled for, as well as considerations of statistical power and analysis, in conjunction with missing data that can affect the outcomes of clinical trials [116] (Fig