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Severe gastrointestinal condition (gastroparesis, inflammatory bowel disease) 10

In addition to the traditionally recognized mechanisms of peripheral nerve damage and central sensitization, excessive iron accumulation, oxidative stress, neuronal inflammation, and lipid peroxidation damage are distinctive features of NP in pathophysiology

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The oxidation of NADPH to NADP + is accompanied by a decrease in absorbance at 340 nm and is directly proportional to the GR activity in the sample

Second, the elevation of pentose phosphate pathway genes, including G6PD and 6-phosphogluconate dehydrogenase, facilitates purine biosynthesis and NAD(P)H generation, resulting in enhanced cell proliferation 37