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Metabolic research has shown improvements in insulin sensitivity and glucose metabolism in some models, suggesting potential applications in metabolic syndrome and age-related metabolic dysfunction

Increased ROS levels can damage mitochondria, reduce mitochondrial activity and activate c-Jun-N-terminal Kinase (JNK) and SREBP, which could lead to lipid droplet accumulation in glial cells (23)

High fat diet feeding impairs neutrophil phagocytosis, bacterial killing, and neutrophil-induced hematopoietic regeneration

However, these combination therapies have not shown a significant increase in overall survival compared to chemotherapy alone [35,36,37,38]

Interestingly, ADNP mutations were found in postmortem AD olfactory bulbs and hippocampi [348]

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