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An additional observation is that in normal physiological conditions, glutamate is maintained at low levels in the brain

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Conditions such as malnutrition, alcoholism, certain medical conditions (e.g., Crohns disease, celiac disease), or restrictive diets (e.g., veganism without adequate supplementation for *B12*) can lead to deficiencies in one or more of these crucial vitamins

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Vitamin B12 also plays a role in the creation of serotonin

Patients reported firmer, better-fitting skin in other areas of the face and neck, as well