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If you look at the methods of the papers inside the review, it kind of covers a large spectrum of what we would consider those athletes

A statistical analysis of 11 studies found metformin at doses of 1,700 mg per day increased serum homocysteine and decreased folic acid levels in non-pregnant women with PCOS

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This creates a devastating feedback loop: the lack of glutathione allows oxidative stress to run rampant, which further impairs the methylation cycle, which in turn prevents the production of more glutathione