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Consistent with the hypothesis that BDNF functions to modulate synaptic strength through the CAMKII calcium signalling pathway, the CAMKII inhibitor KN-93 blocks the effect of BDNF on glioma glutamatergic current amplitude, whereas the inactive analogue KN-92 does not (Fig

Other contributors may include mast-cell activation, allergy, chronic inflammation, medication effects or reduced intracellular breakdown by HNMT

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