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Determinants of human plasma glutathione peroxidase (GPx-3) expression

Excessive MDA in liver tissue will consume a large amount of antioxidative factors, such as SOD and GSH, which can protect liver from the attacks of free radicals, but once the balance is broken, SOD and GSH will be unable to protect liver against the excessively increased MDA (22,23)

Its role as the body's primary endogenous antioxidant means it works at the cellular level to support the entire antioxidant network, rather than functioning as a single-point intervention

10.1038/s41418-019-0304-y Cell Death Differ

In a randomised, double-blind, placebo-controlled, crossover trial (NCT04463030), liposomal vitamin C significantly improved plasma ascorbate and cellular antioxidant protection at 2 h post-consumption, which remained elevated at 6 h compared with placebo and regular vitamin C