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Front Bio sci 2004

Kubik LL, Philbert MA

ROS can initiate different modes of cell death through their oxidative effects on specific redox-sensitive proteins

Around 500 million years ago, coinciding with the colonization of terrestrial environments and the advent of a more complex nervous system during the CambrianDevonian periods, microglia and oligodendrocyte lineages are thought to have emerged (Freeman and Rowitch, 2013)