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The physiological iron supply mostly depends on macrophage-mediated recycling of erythrocyte iron over complex regulatory routes

In contrast, ferroptosis suppressor protein 1 (FSP1, also known as AIFM2) can potently inhibit this form of cell death (Doll et al., 2019) by inducing coenzyme Q10 (CoQ10) production and thereby suppressing lipid peroxidation (Bersuker et al., 2019)