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RCT, randomized controlled trial

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Redon S, Mareau C, Guedj E, Donnet A

The authors conclude: It is evident that neither plasma T4 nor plasma T3 alone permit the prediction of the degree of change in T4 and T3 concentrations in tissues the current replacement therapy of hypothyroidism [giving T4] should no longer be considered adequate. The second study utilizing an experimental model compared plasma TSH, T4 and T3 levels and 13 different tissue levels of T4 and T3 when T4 or T4/T3 treatments were utilized

doi: 10.1186/s13643-019-1202-6 25 PetersonSMcAninchEBiancoA