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The global progress of soil-transmitted helminthiases control in 2020 and world health organization targets for 2030

640 In the DPN study, tanezumab provided effective pain reduction in DPN, with no safety concerns observed

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This facilitates transmembrane flow of Na + , K + , and Ca 2+ , inducing cell membrane depolarization and activating downstream signaling cascades (Figure 2) (McKay et al., 2007)